• Home
  • NFL

New York Giants at San Francisco 49ers Live Stream & Tips – 49ers To Cover Big NFL Thursday Spread

21 Sep 2023
Leigh Copson 21 Sep 2023
Share this article
Or copy link
success image
  • New York Giants at San Francisco 49ers tips for Thursday, September 21
  • Matchup gets underway at 01:15 BST (Friday) at Levi’s Stadium
  • Can the 49ers improve to 3-0 in their home opener?
(Getty Images)
    New York Giants at San Francisco 49ers Predictions & Tips
  • New York Giants at San Francisco 49ers Predictions & Tips
  • Head To Head
  • New York Giants Form
  • San Francisco 49ers Form

New York Giants at San Francisco 49ers Predictions & Tips

San Francisco are tipped to cover a double digit spread.

The defense is unlikely to have many issues slowing a New York offense without Saquon Barkley.

And on the opposite side of the football, the offense is backed to continue putting up plenty of points.

  • San Francisco have covered in each of their last 7 home games
  • The 49ers have covered in 4 of the last 5 games against New York
  • New York Giants are yet to cover the spread in 2023
  • The Under has hit in 8 of San Francisco’s last 14 non-division games

Head To Head

  • The all-time series is tied 21-21
  • San Francisco 49ers won 36-9 when the teams last met in September 2020

New York Giants Form

New York head to San Francisco on a short week looking to build on their first win of the season.

The Giants made it all the way to the playoffs in Brian Daboll’s first season as head coach, and hopes were high coming into the 2023 season.

They got off to a miserable start though, getting shut out as they suffered an embarrassing 40-0 loss at home to Dallas.

New York needed to issue an immediate response last weekend, and while they got the win they needed in Arizona, it was an ugly one.

The Giants trailed 20-0 at the half to one of the worst teams in the league, but found some life on offense after the restart as they out-scored the Cardinals 31-8 to win the game 31-28.

San Francisco 49ers Form

San Francisco go into their home opener with a perfect record, thanks to back-to-back road wins.

Much is expected of the 49ers this season, after they saw their 2022 campaign get derailed by a bunch of injuries to quarterbacks, and they sent a message on opening night.

They dominated the Pittsburgh Steelers on route to a 30-7 victory, with the defense sacking Kenny Pickett five times and picking him off twice.

San Francisco made harder work of their Week 2 outing in Los Angeles, but they did leave with a 30-23 victory.

The 49ers defense again record two interceptions, while Christian McCaffrey rushed for over 100 yards and a touchdown for the second game in a row.


Losing Saquon Barkley on a short week on the road is horrendous news for New York.

Without their biggest weapon it is very difficult to see the Giants hanging with San Francisco here.

Best Bet: San Francisco -10.5 Spread @9/10 at bet365 - 4 Units
Value Bet: Under 45.0 Total Points @9/10 at Betgoodwin - 2 Units
San Francisco -10.5
@9/10 - 4 Units
Bet £10 Get £30
with bonus code NEWBONUS

Available to new customers only. Make a qualifying deposit of £5 or more and claim the offer within 30 days of registering your account to qualify for 300% of that amount in Bet Credits, up to a maximum of £30 in Bet Credits. Once released, your Bet Credits will be held in your account balance and are non-withdrawable. Min deposit requirement. Free Bets are paid as Bet Credits and are available for use upon settlement of qualifying bets. Min odds, bet and payment method exclusions apply. Returns exclude Bet Credits stake. Registration required. Time limits and T&Cs apply.

Bet at bet365
Under 45.0
Total Points
@9/10 - 2 Units
with promo code NEWBONUS

Join betgoodwin with promo code NEWBONUS and get access to their £25 loss back offer. 18+ only. T&Cs apply.

Bet at Betgoodwin

Top Betting Sites

special-offer-1Betting offers

22 Sep 2023

NY Giants @ SF 49ers