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San Francisco 49ers at Denver Broncos Predictions & Tips – San Francisco To Win Low-Scoring NFL Game

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  • San Francisco 49ers at Denver Broncos tips for Sunday, September 25
  • Matchup gets underway at 01:20 BST (Monday) at Empower Field At Mile High
  • Preview, stats & head-to-head
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    San Francisco 49ers at Denver Broncos Predictions & Tips
  • San Francisco 49ers at Denver Broncos Predictions & Tips
  • Head To Head
  • San Francisco 49ers Form
  • Denver Broncos Form
  • San Francisco 49ers at Denver Broncos FAQs

San Francisco 49ers at Denver Broncos Predictions & Tips

San Francisco are tipped to make it back-to-back wins.

Denver’s offense is yet to get going with Russell Wilson at the controls, and that spells trouble here.

This 49ers defense is likely to shut them down, leaving the offense with a low target to get the win.

  • San Francisco are 10-4 in their last 14 games as a betting favourite
  • Denver are 3-7 in their last 10 games as a home betting underdog
  • The Under has hit in both of San Francisco’s games so far
  • The Under has cashed in both of Denver’s games this season

Head To Head

  • San Francisco 49ers lead the all-time series 8-7
  • San Francisco 49ers won 20-14 when the teams last met in September 2018

San Francisco 49ers Form

San Francisco are seeking back-to-back wins after bouncing back from a shock season-opening loss.

The 49ers blew a 10-point lead to suffer a 19-10 defeat in Chicago in Week 1, but were able to get their first win board a week later.

They won 27-7 at home to Seattle despite losing starting QB Trey Lance to a season-ending injury in the first quarter.

His replacement, Jimmy Garoppolo, went 13/21 for 154 yards and a touchdown in the victory.

The 49ers leaned on the run game and tough defense, with Jeff Wilson rushing for 84 yards and Deebo Samuel going for 53 yards on the ground.

Wilson has now carried the ball 27 times for a team-leading 106 rushing yards, while Samuel has rushed for 105 yards and a score to go along with his 58 receiving yards.

Brandon Aiyuk is San Francisco’s leading receiver through two games, catching seven of his targets for 103 yards.

On the opposite side of the football, this defense has been dominant despite the 1-1 record.

They rank #3 in the league in points allowed per game (13.0) and #1 in the NFL in yards allowed per game.

The 49ers are also averaging 2.0 takeaways per game through the first two games of the season.

Denver Broncos Form

Denver have gone 1-1 through their first two games, as the offense continues to falter.

The Broncos opened the season with a 17-16 defeat at Seattle, but got off the mark last Sunday.

It was not pretty though, as they put up just 16 points once again in a 16-9 success at home to Houston.

Russell Wilson finished just 14/31 for 219 yards, one touchdown and one interception in another poor showing.

Courtland Sutton was on the receiving end of seven of those catches as he led the team with 122 yards receiving.

RBs Javonte Williams and Melvin Gordon combined for 122 rushing yards but neither man found the endzone.

Denver desperately need improvement on offense, with big offseason signing Wilson now just 43/73 for 559 yards, two TDs and one pick through two games.

Sutton is the team’s leading receiver with 194 yards, while Jerry Jeudy has 113 yards and a score.

Out of the backfield, the combination of Williams and Gordon have combined for 318 yards from scrimmage.

The defense has been key for Denver so far, allowing just 13.0 points and 243.5 yards per game to rank #3 in both areas.

San Francisco 49ers at Denver Broncos FAQs

Where can I watch the San Francisco 49ers at Denver Broncos live stream?

You can watch the San Francisco 49ers at Denver Broncos live stream at Stake.

What is the San Francisco 49ers at Denver Broncos start time?

The San Francisco 49ers at Denver Broncos game is set to start at 01:20 BST on Monday morning.



San Francisco transitioning from Lance to Garoppolo is not a huge problem.

The 49ers are all about a good run game and dominant defense, and that combination is backed to lead them to victory here.

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26 Sep 2022

SF 49ers @ DEN Broncos