2022 Six Nations Odds – England big favourites for Wales clash

England are 1/7 favouites at Coral, with the bookmaker giving Eddie Jones' side a 13 point head-start in the handicap betting.

Wales are 11/2 to cause an upset and win at Twickenham.

"England and Wales lock horns at Twickenham this weekend in the next instalment of their fierce rivalry,” Coral's Harry Aitkenhead told FreeTips.com/

“However, the betting predicts a one-sided affair. England are overwhelming odds on favourites to run out victors.”

France are odds on to win the Six Nations, at 1/2, while it is 6/4 that they complete the Grand Slam.

Ireland are 7/2 second favourites, followed by England at 11/2.

"France have one hand on the trophy already it seems,” Aitkenhead added.

1/7 England, 11/2 Wales, 25/1 Tie

10/11 England -13,  10/11 Wales +13

1/2 France, 7/2 Ireland, 11/2 England, 18/1 Scotland, 40/1 Wales, 1000/1 Italy

1/2 No, 6/4 Yes