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Chicago White Sox at Cleveland Guardians Betting Tips – White Sox To Take Game 5 In MLB Playoffs

leigh-copson
Editor
Last updated: Fri 09 Oct 2026 14:09
The Chicago White Sox are predicted to pull off an upset over the Cleveland Guardians in Game 5 of their playoff series. Chicago has already won twice in Cleveland this series, and Sean Burke, who delivered a strong relief performance earlier, will benefit from a fresher bullpen. While Cleveland leads the all-time head-to-head and won the last meeting, the White Sox’s previous road success in Cleveland, coupled with the pitching matchup, makes them a compelling underdog pick to advance.
Leigh Copson 2 hours ago
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  • Chicago tipped to upset Guardians in Game 5, having already won twice in Cleveland
  • Sean Burke starts with a rested bullpen; impressed in Game 2 meeting
  • Guardians starter Gavin Williams is 0-3 vs Chicago in his last three meetings
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Chicago are tipped to pull off an upset and win Game 5 on the road.

The White Sox have already won twice in Cleveland in this series, and not only did Sean Burke do a great job in relief in Game 2, he will be supported by a fresher bullpen after the Guardians emptied theirs on Thursday night.

Key Numbers - Can Sox Go 3-0 In Cleveland In This Series?

  • Chicago won the 2 previous meetings in Cleveland in this playoff series
  • Sean Burke allowed just 1 hit and 1 earned run in 5.1 innings in Game 2
  • Cleveland starter Gavin Williams is 0-3 in his last 3 meetings with Chicago
  • The Over has cashed in 3 of the 4 games in this series

Guardians Lead All-Time Head-To-Head; Won Last Meeting

  • Cleveland Guardians lead the all-time series 1143-1140-17
  • This playoff series is tied at 2-2
  • Cleveland Guardians won 9-5 when the two teams last met on October 8

Chicago White Sox Form - White Sox Lost Back-To-Back Games

Chicago head back to Cleveland having passed up the opportunity to clinch the series at home, losing back-to-back games.

DatePlayoff OppositionW/LScore
Sep-29 at Houston Astros W 6-3
Sep-30 at Houston Astros W 7-3
Oct-03 at Cleveland Guardians W 3-0
Oct-05 at Cleveland Guardians W 4-3
Oct-07 vs Cleveland Guardians L 3-9
Oct-08 vs Cleveland Guardians L 5-9

Cleveland Guardians Form - Guardians Forced Game 5

Cleveland return home having fended off elimination with back-to-back wins in Chicago, setting up this winner-takes-all Game 5 showdown.

DatePlayoff OppositionW/LScore
Oct-03 vs Chicago White Sox L 0-3
Oct-05 vs Chicago White Sox L 3-4
Oct-07 at Chicago White Sox W 9-3
Oct-08 at Chicago White Sox W 9-5

Starting Pitchers

PlayerTeamRecordERAStrikeoutsInnings
Sean Burke Chicago White Sox 11-7 3.34 185 172.1
Gavin Williams Cleveland Guardians 14-8 3.76 248 184.1

Verdict

Chicago blew their chance to wrap things up at home, but they make for an appealing underdog on the road.

The White Sox are 2-0 in Cleveland in this series and starter Burke has shut down the Guardians once already, so give us the visitors and the plus-money here.

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leigh-copson
Leigh Copson

Sports Editor • 25+ Years Experience, US & Combat Sports Specialist

US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.

During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.

He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.

Follow more of Leigh's work on Muckrack and connect with him on LinkedIn.

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