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Minnesota Twins at San Francisco Giants Betting Tips – Twins To Earn 3rd Win On MLB Road Trip

leigh-copson
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Last updated: Mon 21 Sep 2026 09:09
The Minnesota Twins are tipped to open their road series against the San Francisco Giants with a victory. Although both teams are out of playoff contention, the Twins enter with momentum after recent wins and will face a Giants squad plagued by injuries and poor form. The Twins have a historical edge in recent matchups, having swept the Giants last season, and both starting pitchers sport high ERAs, suggesting a potential for scoring. Expect Minnesota to capitalize on these advantages in this series opener.
Leigh Copson 1 hour ago
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  • Twins favored to win series opener vs injury-hit Giants
  • Both teams out of playoff contention, but Twins in better form
  • Pitchers' high ERAs could mean a high-scoring game
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Minnesota are tipped to open this series with a victory.

The Twins picked up a couple of wins in Los Angeles last week, and they can take advantage of a Giants team dealing with a bunch of injuries at this time.

Key Numbers – Can Twins Go 3-2 On Road Trip?

  • Minnesota Twins have won 2 of their 4 games on this road trip
  • San Francisco Giants have lost 5 of their previous 9 home games
  • Minnesota Twins won all 3 meetings with San Francisco last season
  • The two starting pitchers have a combined ERA of 9.28

Giants Lead All-Time Head-To-Head; Twins Won Last Meeting

  • San Francisco Giants lead the all-time series 20-19
  • Minnesota Twins won 7-6 when the two teams last met in May 2025

Minnesota Twins Form – Last 10 Games

Minnesota head to the Bay Area having lost six of their previous 10 games, and having split their first four games on this road trip.

DateOppositionW/LScore
Sep-11 vs Cleveland Guardians L 2-5
Sep-12 vs Cleveland Guardians W 4-3
Sep-13 vs Cleveland Guardians L 2-9
Sep-14 vs New York Yankees L 3-8
Sep-15 vs New York Yankees L 1-8
Sep-16 vs New York Yankees W 5-4 W/O
Sep-17 at Los Angeles Angels L 4-5 W/O
Sep-18 at Los Angeles Angels W 3-0
Sep-19 at Los Angeles Angels L 5-6 W/O
Sep-20 at Los Angeles Angels W 8-0

San Francisco Giants Form – Last 10 Games

San Francisco go into their penultimate series of the season in miserable form, having lost seven of their last nine games and each of the last three.

DateOppositionW/LScore
Sep-09 vs St Louis Cardinals W 7-6
Sep-11 vs San Diego Padres L 5-7
Sep-12 vs San Diego Padres L 6-7
Sep-13 vs San Diego Padres L 4-6
Sep-14 at St Louis Cardinals L 1-2
Sep-15 at St Louis Cardinals W 10-3
Sep-16 at St Louis Cardinals W 6-5
Sep-18 at Los Angeles Dodgers L 2-8
Sep-19 at Los Angeles Dodgers L 4-10
Sep-20 at Los Angeles Dodgers L 1-3

Starting Pitchers

PlayerTeamRecordERAStrikeoutsInnings
Zebby Matthews Minnesota Twins 9-10 4.74 107 125.1
Blade Tidwell San Francisco Giants 1-2 4.56 42 53.1

Verdict

Neither team is playoff bound, but both will want to at least finish the season with some positive outings.

This could be a good outing for the Twins, who get to face a hittable pitcher and an injury-hit Giants team.

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leigh-copson
Leigh Copson

Sports Editor • 25+ Years Experience, US & Combat Sports Specialist

US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.

During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.

He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.

Follow more of Leigh's work on Muckrack and connect with him on LinkedIn.

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