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Ohio State at Indiana Betting Tips – Back Buckeyes In Huge College Football Clash

leigh-copson
Editor
Last updated: Mon 12 Oct 2026 13:33
Ohio State are favored to cover the spread as they visit defending national champions Indiana. While Indiana remain unbeaten, their recent Big Ten performances have been less convincing, narrowly surviving against stronger opponents. Ohio State, riding a four-game win streak and with a standout offense and solid defense, are tipped to seize this crucial conference matchup, despite Indiana's home-field advantage. The article concludes by recommending Ohio State as the better pick for this contest.
Leigh Copson 1 hour ago
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  • Ohio State tipped to cover the spread against Indiana
  • Indiana have been less convincing in close Big Ten encounters
  • Ohio State ride four-game win streak; strong offense & defense expected to be decisive
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Ohio State are tipped to cover as they beat the defending national champions on the road.

Indiana may be unbeaten, but they were pushed to the limit by Northwestern and survived a scare to edge past Nebraska last week.

The defense remains rock solid, but the Buckeyes offense has the talent to do some damage here, while their own defense makes the stops needed to get the job done.

Key Numbers – Can Buckeyes Go 6-1 This Season?

  • Ohio State have won 5 of their 6 games so far
  • Ohio State covered in their 2 previous road games
  • Indiana have failed to cover in 5 of their 6 games
  • These two defenses are allowing a combined 27.4 points per game

Ohio State Lead All-Time Head-To-Head; Indiana Won Last Meeting

  • Ohio State lead the all-time series 81-13-5
  • Indiana won 13-10 when the two teams last met in December 2025

Ohio State Riding Four-Game Win Streak

Ohio State head out on the road having rebounded from the defeat in Texas with four straight wins to reach 5-1.

The Buckeyes opened the season with a 56-3 blowout of an overmatched Ball State team, but failed to follow that up a week later as they were narrowly beaten 24-23 at Texas.

They issued an immediate response though, crushing Kent State 59-3, and have backed that up with three straight wins in Big Ten action.

Ohio State kicked off their conference campaign with a 42-19 victory over Illinois, and then travelled to Iowa where they recorded a 31-14 win against the Hawkeyes.

The Buckeyes then made it four-in-a-row – and went 3-0 in the Big Ten – by downing Maryland 45-16 last weekend.

Indiana Unbeaten After Six Games

Defending national champions Indiana enter this matchup having survived a scare to maintain their perfect record.

The Hoosiers kicked off their defence of the national crown with three consecutive blowout wins over non-conference opposition.

They dominated North Texas in a 42-16 victory, and backed that up with shutout successes against both Howard, 55-0, and Western Kentucky, 38-0.

Indiana then began their Big Ten slate with a hard-earned 29-23 win over Northwestern, before beating Rutgers 47-15 on the road.

The Hoosiers made it three-in-a-row in the conference – and 6-0 overall – as they came from behind to win 20-17 in Nebraska last time out.

Verdict

Going against the national champions at home is a risky proposition, but we like what we have seen from Ohio State so far.

Indiana are winning games, but it would not be unfair to say that they have underwhelmed in a couple of their Big Ten games so far.

The Buckeyes do not have the holes that Northwestern and Nebraska have, so we are backing Ryan Day’s men to take this crucial conference clash.

Best Bet1: Ohio State -3.5 Spread @9/10 at bet365 - 4 Units
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leigh-copson
Leigh Copson

Sports Editor • 25+ Years Experience, US & Combat Sports Specialist

US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.

During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.

He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.

Follow more of Leigh's work on Muckrack and connect with him on LinkedIn.

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