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Buffalo Bills at Los Angeles Rams Betting Tips – Rams To Win Monday NFL Shootout

leigh-copson
Editor
Last updated: Fri 09 Oct 2026 13:33
The Los Angeles Rams are predicted to win and cover the spread in their Monday Night Football matchup against the Buffalo Bills. Buffalo is coming off their first defeat of the season and has struggled with turnovers and defensive issues. The Rams, bolstered by the return of Puka Nacua, look set to exploit the Bills' weaknesses, building on recent strong performances, particularly at home. Both teams have seen high-scoring games, which points to a potential shootout.
Leigh Copson 2 hours ago
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  • Rams tipped to win and cover in a potential high-scoring shootout against Bills
  • Buffalo's recent struggles with turnovers and defense could be exploited by Los Angeles
  • Return of Puka Nacua boosts the Rams’ offense as they seek consecutive wins
(Getty Images)

Los Angeles are tipped to cover as they win a Monday Night Football shootout.

Buffalo’s offense has been sloppy with the football over the past couple of games, while the defense has been a real problem for them through four weeks.

Matthew Stafford, Puka Naku et al. can take full advantage to come away with the victory.

Key Numbers – Will Rams Make It 3 Covers In 3 Wins?

  • Los Angeles Rams have covered in their 2 wins this season
  • Buffalo Bills are coming off a home defeat to New England
  • Los Angeles Rams have covered in 7 of their last 9 games at SoFi Stadium
  • The Over has cashed in each of Los Angeles’ last 2 games
  • The Over has hit in 3 of Buffalo’s 4 games this season

Bills Lead All-Time Head-To-Head; Rams Won Last Meeting

  • Buffalo Bills lead the all-time series 9-6
  • Los Angeles Rams won 44-42 when the two teams last met in December 2024

Buffalo Bills Suffered First Loss Last Time Out

Buffalo make the long trip to California looking to rebound from their first defeat of the season, which dropped them to 3-1.

The Bills kicked off the campaign on the road and enjoyed a successful start as they beat Houston 36-31.

They then followed that up in their home opener as they marked the official opening of their new stadium with a 41-31 victory over Detroit.

Buffalo made it three-in-a-row with a 25-16 win against the Los Angeles Chargers, but that would prove to be the end of their win streak.

The Bills hosted division rivals New England last weekend, and suffered a surprise 29-26 defeat to the Patriots.

Los Angeles Rams 2-2 Following Road Win

Los Angeles return home looking to win back-to-back games for the first time this season.

The Rams opened the season by making the long trip to Australia for a showdown with division rivals San Francisco, and their travel plans appeared to backfire on them.

They lost that matchup 27-7, but rebounded the following week with a 28-6 success when they hosted the New York Giants.

Los Angeles failed to make it consecutive wins as they then fell 30-26 in Denver, but they did issue an immediate response.

The Rams returned to winning ways last Sunday as they travelled to Philadelphia and downed the Eagles, 24-20.

Verdict

Los Angeles have struggled for consistency so far, but the return of Nacua is a big boost for this offense, and they now get to face a struggling Bills defense.

The Rams can light up the visitors in this one, ensuring they come out on the winning end of what could be a high-scoring shootout.

Best Bet1: Los Angeles -3.5 Spread @20/21 at bet365 - 4 Units
Best Bet2: Over 54.5 Total Points @9/10 at dabble - 2 Units
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leigh-copson
Leigh Copson

Sports Editor • 25+ Years Experience, US & Combat Sports Specialist

US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.

During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.

He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.

Follow more of Leigh's work on Muckrack and connect with him on LinkedIn.

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