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Ohio State at USC Betting Tips – Back Buckeyes For College Football Cover

leigh-copson
Editor
Last updated: Tue 27 Oct 2026 11:56
Ohio State are tipped to cover the spread as they visit USC, aiming for a sixth consecutive win. Despite the loss of starting quarterback Julian Sayin, Ohio State’s elite defence is expected to compensate and help secure the cover. The Buckeyes have covered in all three road games this season and are riding a five-game win streak, while USC have failed to cover in six of eight games. Although USC lead the all-time series, Ohio State won the last meeting and their defensive strength is highlighted as the decisive factor.
Leigh Copson 1 hour ago
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  • Ohio State tipped to cover spread against USC
  • Buckeyes have covered in all three road games; on a five-game win streak
  • Ohio State’s defense is expected to offset absence of quarterback Julian Sayin
(Getty Images)

Ohio State are tipped to cover as they make it six wins in a row.

The loss of starting quarterback Julian Sayin does leave some question marks surrounding the offense, but this elite Buckeyes defense can pick up any slack to help ensure the cover.

Key Numbers – Will Buckeyes Make It 6-In-A-Row?

  • Ohio State are on a 5-game win streak
  • Ohio State have covered in all 3 of their road games so far
  • USC have failed to cover in 6 of their 8 games this season
  • The Under has cashed in all 3 of Ohio State’s road games

USC Lead All-Time Head-To-Head; Ohio State Won Last Meeting

  • USC lead the all-time series 13-10-1
  • Ohio State won 24-7 when the two teams last met in December 2017

Ohio State Riding Five-Game Win Streak

Ohio State head to California having rebounded from their sole defeat of the season so far, winning five straight games to improve to 6-1.

The Buckeyes kicked off the campaign with a 56-3 demolition of Ball State, but came up short in their first real test as they fell 24-23 at Texas.

They rebounded immediately with a 59-3 blowout of Kent State, and have backed that up by winning the first four games on their Big Ten slate.

Ohio State downed Illinois 42-19 at home, and followed that up with wins at Iowa, 31-14, and at home to Maryland, 45-16.

The Buckeyes then knocked off defending champions Indiana on the road, beating the Hoosiers 19-15 in their last outing.

USC Suffered Second Loss Last Weekend

USC enter this matchup on the back of their second loss of the season, which has most likely ended their chances of making the Big Ten Championship.

The Trojans kicked off the campaign by winning three straight non-conference games, beating San Jose State 42-26, Fresno State 39-0 and Louisiana 49-30.

They then began their Big Ten schedule with a 42-35 win at Rutgers, but failed to follow that up a week later as they lost 41-27 at home to Oregon.

USC bounced back to down Washington 25-21, and then headed to Penn State for a 31-23 victory over the Nittany Lions.

The Trojans failed to make it three-in-a-row however, as they were beaten 24-7 in Wisconsin last weekend.

Verdict

The injury to Sayin is a massive blow for Ohio State, but they still boast one of the best defenses in college football.

The Buckeyes can shut down the Trojans here, ensuring they leave with the victory and the cover.

Best Bet1: Ohio State -6.5 Spread @4/5 at bet365 - 4 Units
Best Bet2: Under 51.5 Total Points @5/6 at dabble - 2 Units
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leigh-copson
Leigh Copson

Sports Editor • 25+ Years Experience, US & Combat Sports Specialist

US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.

During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.

He has also covered almost every major boxing match and UFC fight card during this time. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.

Follow more of Leigh's work on Muckrack and connect with him on LinkedIn.

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