Detroit Lions at Arizona Cardinals Betting Tips – Lions To Win NFL Shootout In The Desert

Leigh Copson

Editor

Last updated: Thu 08 Oct 2026 13:17

Leigh Copson 1 hour ago

Share this article

Detroit are favoured in a likely high-scoring game against Arizona
Arizona is on a three-game losing streak, having struggled defensively
Lions’ stronger offense and recent head-to-head win give them the edge

(Getty Images)

Detroit Lions at Arizona Cardinals Betting Tips

Key Numbers – Will Arizona Avoid 4th Straight Defeat?
Lions Lead All-Time Head-To-Head; Won Last Meeting
Detroit Lions 2-2 Following Monday Night Loss
Arizona Cardinals On 3-Game Losing Skid

Detroit are tipped to win a high-scoring shootout in Arizona.

Both defenses have been getting gashed this season, so these two offenses should have plenty of opportunities to put up points in this one.

For that reason we have to go with a Lions team that has the better quarterback in Jared Goff, and more weapons on offense.

Key Numbers – Will Arizona Avoid 4th Straight Defeat?

Arizona Cardinals have lost 3 straight games
Arizona Cardinals lost by 24 points in their only other home game
Detroit Lions have out-scored Arizona 119-97 this season
The Over has cashed in all 4 of Detroit’s games so far this season

Lions Lead All-Time Head-To-Head; Won Last Meeting

Detroit Lions lead the all-time series 38-28-6
Detroit Lions won 20-13 when the two teams last met in September 2024

Detroit Lions 2-2 Following Monday Night Loss

Detroit head out on the road for the second week running, looking to rebound from the loss that dropped them to 2-2.

The Lions made a winning start to the season as they beat New Orleans 31-30 in overtime at home, but they failed to build on that.

Despite another strong outing from the offense in Buffalo, they fell to a 41-31 defeat at the hands of the Bills.

Detroit issued an immediate response when they returned home to down the New York Jets 31-24, only to again fail to follow up victory.

This time the Lions paid a visit to Carolina for Sunday Night Football, and suffered a 32-26 defeat to the Panthers.

Arizona Cardinals On 3-Game Losing Skid

Arizona enter this matchup having failed to back up a season-opening win, losing three straight games.

The Cardinals kicked off the campaign with a visit to the Los Angeles Chargers, and pulled off a shock 26-14 victory.

However, it has been all downhill since then, with the 31-7 blowout loss in the home opener against Seattle proving to be the start of a three-game skid.

Arizona lost to another division rival a week later as they dropped a close one at San Francisco, 36-30.

The Cardinals’ poor run then reached three games last Sunday as they suffered a 36-24 defeat at the New York Giants.

Verdict

DET Lions @ ARZ Cardinals

Both defenses have given up a ton of points so far, so we expect this to descend into something of a shootout.

And if that is the case, the Lions have to be the pick thanks to a high-scoring offense that is loaded with talent.

Detroit -5.5

Spread

@9/10 - 4 Units

Bet £10 Get £30

with bonus code NEWBONUS

Available to new customers only. Make a qualifying deposit of £5 or more and claim the offer within 30 days of registering your account to qualify for 300% of that amount in Bet Credits, up to a maximum of £30 in Bet Credits. Once released, your Bet Credits will be held in your account balance and are non-withdrawable. Min deposit requirement. Free Bets are paid as Bet Credits and are available for use upon settlement of qualifying bets. Min odds, bet and payment method exclusions apply. Returns exclude Bet Credits stake. Registration required. Time limits and T&Cs apply. The bonus code NEWBONUS can be used during registration but does not change the offer amount in any way. #ad

Bet at bet365

Over 54.5

Total Points

@9/10 - 2 Units

Bet £10 Get £10

Promo Code: NEWBONUS

New customers only. Bet £10+ to receive £10 in Free Bets. 7-day free bet expiry. Stake not returned. Promotional Terms Apply. 18+. GambleAware.org

Bet at dabble

US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.

During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.

He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.

Follow more of Leigh's work on Muckrack and connect with him on LinkedIn.