Los Angeles Chargers at Buffalo Bills Betting Tips – Bills To East Past Chargers In NFL

Leigh Copson

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Last updated: Wed 23 Sep 2026 11:35

Leigh Copson 1 hour ago

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Bills have scored 77 points in first two games and are 2-0
Chargers are winless at 0-2, struggling on both sides of the ball
Prediction: Buffalo to win & cover, led by red-hot offense

(Getty Images)

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Los Angeles Chargers at Buffalo Bills Betting Tips

Key Numbers – Will Bills Go 3-0 This Sunday?
Chargers Lead All-Time Head-To-Head; Bills Won Last Meeting
Los Angeles Chargers Winless After 2 Games
Buffalo Bills Take Perfect 2-0 Record Into Week 3

Buffalo are tipped to cover as they make straightforward work of the Chargers.

Josh Allen and the Bills offense are off to a red-hot start, and they can set a scoring pace that the visitors simply cannot match.

Key Numbers – Will Bills Go 3-0 This Sunday?

Buffalo Bills have covered in their first 2 wins
Buffalo Bills have scored 77 points across the first 2 weeks
Los Angeles Chargers failed to cover in their first 2 defeats
The Over has cashed in each of Buffalo’s first two games

Chargers Lead All-Time Head-To-Head; Bills Won Last Meeting

Los Angeles Chargers lead the all-time series 25-14-2
Buffalo Bills won 24-22 when the two teams last met in December 23

Los Angeles Chargers Winless After 2 Games

Los Angeles head out on the road for the first time this season still seeking a first victory of 2026.

The Chargers opened the campaign with back-to-back home games, but failed to make the most of that as they lost both of them.

They kicked off the campaign with a 26-14 loss to Arizona, and then lost by the exact same score when they hosted division rivals Las Vegas last weekend.

Quarterback Justin Herbert was just 15/27 for 192 yards, one touchdown and two interceptions.

Running back Omarion Hampton did offer one bright spot on offense as he put up 115 total yards and a touchdown in the loss.

Buffalo Bills Take Perfect 2-0 Record Into Week 3

Buffalo go into their second consecutive home game boasting a perfect record thanks to back-to-back victories.

The Bills opened the season with a trip to face a tough Houston defense, but Josh Allen & Co. was able to light up the Texans to secure a 36-31 victory.

They topped that performance in their home opener last weekend, as they hung 41 points on Detroit in a 41-31 success.

Quarterback Allen went 20/31 for 248 yards and three touchdowns, while also rushing for 69 yards and two touchdowns.

Running back James Cook racked up 135 yards and a touchdown off 21 carries, while Dalton Kincaid caught the ball seven times for 95 yards and a score.

Verdict

LA Chargers @ BUF Bills

Buffalo’s defense has given up a bunch of points so far, but it has not mattered.

Josh Allen is staking an early claim for MVP and this Bills offense is on a tear, so we are backing the hosts to win and cover on Sunday.

Buffalo -7.0

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US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.

During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.

He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.

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