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Chicago White Sox at Cleveland Guardians Betting Tips – Underdog Sox To Win MLB Clash

leigh-copson
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Last updated: Mon 14 Sep 2026 14:30
The Chicago White Sox are looking to capitalize on their slight edge against the Cleveland Guardians in the first game of an important AL Central series. Despite losing eight of their last eleven games, the White Sox have won six out of ten meetings with the Guardians this season. Meanwhile, the Guardians have struggled at home, losing 11 of their last 19 home games. With starting pitchers Sean Newcomb (2.77 ERA) for the White Sox and Gavin Williams (3.78 ERA) for Cleveland, analysts recommend backing the White Sox as a plus-money underdog in this matchup.
Leigh Copson 42 minutes ago
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  • White Sox have won 6 of 10 meetings with Guardians this season
  • Cleveland has lost 11 of last 19 home games
  • White Sox are recommended as a plus-money underdog
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Chicago are tipped to spring an upset in the opening game of this crucial AL Central series.

The White Sox have a slight lead in the season series, and the Guardians possess one of the worst home records in the league.

Key Numbers – Can White Sox Go 7-4 Against Guardians This Season?

  • Chicago White Sox have won 6 of the previous 10 meetings this season
  • Cleveland Guardians have lost 11 of their last 19 home games
  • The Over has cashed in 3 of the previous 4 meetings

Guardians Lead All-Time Head-To-Head; White Sox Won Last Meeting

  • Cleveland Guardians lead the all-time series 1139-1137-17
  • Chicago White Sox won 5-3 when the two teams last met on August 9

Chicago White Sox Form – Last 10 Games

Chicago head to Cleveland on a bad run of form, having just suffered their eighth defeat in their last 11 games.

DateOppositionW/LScore
Sep-03 at Houston Astros L 2-6
Sep-04 vs Minnesota Twins W 4-1
Sep-05 vs Minnesota Twins L 4-6
Sep-06 vs Minnesota Twins W 10-1
Sep-08 vs Pittsburgh Pirates L 3-9
Sep-09 vs Pittsburgh Pirates L 2-4
Sep-10 vs Pittsburgh Pirates L 0-2
Sep-11 at St Louis Cardinals L 3-7
Sep-12 at St Louis Cardinals W 6-5
Sep-13 at St Louis Cardinals L 1-3

Cleveland Guardians Form – Last 10 Games

Cleveland enter this series having won six of their last 10 games, but having not won back-to-back games since September 4.

DateOppositionW/LScore
Sep-04 vs Detroit Tigers W 7-6 W/O
Sep-04 vs Detroit Tigers W 4-3 W/O
Sep-05 vs Detroit Tigers L 0-6
Sep-06 vs Detroit Tigers W 3-2 W/O
Sep-07 at Baltimore Orioles L 4-6
Sep-08 at Baltimore Orioles W 9-5
Sep-09 at Baltimore Orioles L 5-9
Sep-11 at Minnesota Twins W 5-2
Sep-12 at Minnesota Twins L 3-4
Sep-13 at Minnesota Twins W 9-2

Starting Pitchers

PlayerTeamRecordERAStrikeoutsInnings
Sean Newcomb Chicago White Sox 2-4 2.77 78 84.1
Gavin Williams Cleveland Guardians 13-7 3.78 228 169.0

Verdict

Chicago’s current form is underwhelming, but they have had a slight edge over the Guardians this season, and Cleveland have hardly been great at home.

Give us the plus-money in this matchup.

Best Bet1: Chicago Win Moneyline @6/5 at bet365 - 4 Units
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Chicago Win
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leigh-copson
Leigh Copson

Sports Editor • 25+ Years Experience, US & Combat Sports Specialist

During his career he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final. He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.


Follow more of Leigh's work on Muckrack.

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