Louisville vs Ole Miss Betting Tips – Back Cardinals With Free Points In College Football Clash

Leigh Copson

Editor

Last updated: Thu 03 Sep 2026 14:01

Leigh Copson 3 hours ago

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Louisville often covers as underdogs under Coach Brohm
Ole Miss seeking to bounce back from disappointing end to 2025
Betting tip: Louisville +6.5 and Under 55.5 points favoured

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Louisville at Ole Miss Betting Tips

Key Numbers – Will Cardinals Notch 5th Underdog Cover Under Brohm?
Ole Miss Lead All-Time Head-To-Head; Won Last Meeting
Louisville Split ACC Schedule In 2025
Ole Miss Out To Rebound From Playoff Heartbreak

Louisville are tipped to cover as a betting underdog when they visit Ole Miss.

The Rebels bring back key offensive weapons in Chambliss and Lacy, but the Cardinals have playmakers too and head coach Jeff Brohm always has his team ready to play.

Key Numbers – Will Cardinals Notch 5th Underdog Cover Under Brohm?

Louisville have covered in 4 of 7 games as a betting underdog under Jeff Brohm with 1 push
Ole Miss have failed to cover in 3 of their last 6 non-conference games
The Under has cashed in 6 of Louisville’s last 8 regular season games
The Under has hit in 6 of Ole Miss’ last 9 regular season games

Ole Miss Lead All-Time Head-To-Head; Won Last Meeting

Ole Miss lead the all-time series 1-0
Ole Miss won 43-24 when the two teams last met in September 2021

Louisville Split ACC Schedule In 2025

Louisville go into the season-opener looking to rebound from a disappointing ACC campaign in 2025 that saw them split their eight games.

The Cardinals opened the season with three non-conference wins, and then kicked off their ACC slate with a 34-27 win at Pitt.

Their run was ended by a 30-27 loss to Virginia, but they responded strongly and beat Miami FL 24-21, Boston College 38-24 and Virginia Tech 28-16 to propel themselves into the conference championship mix.

Louisville’s form nose-dived after that though, as they lost 29-26 to California, 20-19 to Clemson and 38-6 to SMU to miss out on the ACC showpiece.

The Cardinals did at least rally to end the season on a positive note however, following up a 41-0 blowout of Kentucky with a 27-22 win over Toledo in the Boca Raton Bowl.

Ole Miss Out To Rebound From Playoff Heartbreak

Ole Miss come into the new season looking to rebound from a rough end to the 2025 campaign that saw them lose their head coach and fall in the semi-finals of the College Football Playoffs.

The Rebels roared out of the blocks with a six-game win streak that included SEC wins over Kentucky, 30-23, Arkansas, 41-35, and LSU, 24-19.

That run was ended by a 43-35 loss at Georgia in October, and that proved to be the game that denied them an appearance in the SEC Championship Game.

Ole Miss rallied to win their final five regular season games though, and successfully negotiated the first two rounds of the playoffs as they beat Tulane 41-10 and Georgia 39-34.

However, the Rebels’ quest for national glory came to an end in the Fiesta Bowl, as they were beaten 31-27 by Miami FL.

Verdict

Louisville v Ole MIss

Ole Miss are expected to make a winning start, but we like Louisville’s chances of covering.

The Cardinals have their own weapons on offense, and since Jeff Brohm took over they have developed a healthy knack for covering in the underdog role.

Louisville +6.5

Spread

@9/10 - 3 Units

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Bet at bet365

Under 55.5

Total Points

@9/10 - 3 Units

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During his career he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final. He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.

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