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Oregon at Ohio State Betting Tips – Buckeyes To Lean On Defense In College Football Win

leigh-copson
Editor
Last updated: Thu 05 Nov 2026 16:40
Ohio State are tipped to cover the spread as they host Oregon, aiming to rebound from their second loss of the season. The Buckeyes' offence has struggled without Julian Sayin, but their defence remains a key asset, particularly at home. Oregon have disappointed this season, losing two of their three road games and failing to cover in five of eight. Ohio State lead the all-time series 10-2 and won the last meeting in January 2025. These factors support the selection of Ohio State to cover the spread in this matchup.
Leigh Copson 2 hours ago
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  • Ohio State tipped to cover spread against Oregon
  • Buckeyes' defense is expected to be decisive, especially at home
  • Oregon have lost two of three road games and failed to cover in five of eight
(Getty Images)

Ohio State are tipped to cover as they return to winning ways on Saturday.

The Buckeyes’ offense has struggled without Julian Sayin, but they can lean on a talented defense against an Oregon team that has underwhelmed and not travelled well.

Key Numbers – Will Buckeyes Improve To 7-2?

  • Ohio State have won 6 of their 8 games
  • Oregon have lost in 2 of their 3 road games
  • Oregon have failed to cover in 5 of their 8 games
  • The Under has cashed in 3 of Ohio State’s last 4 games

Ohio State Lead All-Time Head-To-Head; Won Last Meeting

  • Ohio State lead the all-time series 10-2
  • Ohio State won 41-21 when the two teams last met in January 2025

Oregon Registered Fifth Victory Last Weekend

Oregon head to Ohio State having rebounded from their third conference loss of the season to improve to 5-3.

The Ducks made hard work of their 34-27 season-opening win over Boise State, and then suffered a surprise 39-31 defeat at Oklahoma State as their stock plummeted.

They rebounded with an 84-0 shutout of Portland State, before opening their Big Ten campaign with a 41-27 victory at USC.

Oregon failed to make it three-in-a-row though, as they were beaten 21-15 at UCLA, and they were then unable to back up a 17-14 victory over Nebraska, as they lost 21-10 at Illinois.

The Ducks do make this trip on the back of a win though, having downed Northwestern last weekend, 34-26.

Ohio State Suffered Second Loss Last Time Out

Ohio State go into this game looking to rebound from their second defeat of the season, which has left them 6-2.

The Buckeyes opened with three non-conference games, sandwiching a 24-23 defeat at Texas with blowout wins over Ball State, 56-3, and Kent State, 59-3.

They then kicked off their Big Ten schedule with a 41-19 win over Illinois, and backed that up by beating Iowa 31-14 on the road, and Maryland 45-16 at home.

That set up a huge matchup with defending national champions Indiana, and Ohio State overcame the loss of quarterback Julian Sayin as they ground out a 19-15 victory.

However, in their first full game without Sayin, the Buckeyes lost 30-18 at USC last weekend.

Verdict

Ohio State’s first outing without Sayin proved to be a rough one, but they are back home for this one and they do still boast a tough defense.

Therefore we are backing the Buckeyes to bounce back against an Oregon team that has disappointed this season.

Best Bet1: Ohio State -7.5 Spread @9/10 at bet365 - 4 Units
Best Bet2: Under 46.5 Total Points @9/10 at Star Sports - 2 Units
Ohio State -7.5
Spread
@9/10 - 4 Units
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Bet at bet365
Under 46.5
Total Points
@9/10 - 2 Units
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Bet at Star Sports
leigh-copson
Leigh Copson

Sports Editor • 25+ Years Experience, US & Combat Sports Specialist

US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.

During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.

He has also covered almost every major boxing match and UFC fight card during this time. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.

Follow more of Leigh's work on Muckrack and connect with him on LinkedIn.

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