San Francisco 49ers at Atlanta Falcons Betting Tips – Unbeaten 49ers To Cover NFL Spread

Leigh Copson

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Last updated: Wed 21 Oct 2026 16:12

Leigh Copson 3 hours ago

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San Francisco remain unbeaten at 6-0; tipped to cover spread against Atlanta
Falcons have lost two straight games; have failed to cover in all their home games
49ers hold a strong historical edge, winning the last head-to-head 20-10

(Getty Images)

San Francisco 49ers at Atlanta Falcons Betting Tips

Key Numbers – Will 49ers Make It 7-In-A-Row?
49ers Lead All-Time Head-To-Head; Won Last Meeting
San Francisco 49ers Possess Perfect 6-0 Record
Atlanta Falcons 2-4 Following Back-To-Back Defeats

San Francisco are tipped to cover the spread as they remain unbeaten.

Caleb Williams and the Bears had their way with this Falcons defense a week ago, and Brock Purdy & Co. are more than capable of replicating that here.

And on the opposite side of the football, this Niners defense can put the clamps on Bijan Robinson and whoever lines up at quarterback for Atlanta.

Key Numbers – Will 49ers Make It 7-In-A-Row?

San Francisco 49ers have won all 6 of their games
San Francisco 49ers have covered in 4 of their 6 games
Atlanta Falcons have failed to cover in all 3 of their home games so far
4 of San Francisco’s 6 games have produced under 50.5 total points

49ers Lead All-Time Head-To-Head; Won Last Meeting

San Francisco 49ers lead the all-time series 49-33-1
San Francisco 49ers won 20-10 when the two teams last met in October 2025

San Francisco 49ers Possess Perfect 6-0 Record

San Francisco head out on the road having won all six of their games so far, making them one of just three unbeaten teams heading into Week 7.

The 49ers kicked off the season by making the long trip to Australia, but they made it a worthwhile trip as they knocked off division rivals, the Los Angeles Rams, 27-7.

They then followed that up when they returned home to beat Miami 35-13 and Arizona 36-30.

San Francisco made it four-in-a-row with a 24-14 success against Denver, and then downed defending Super Bowl champions Seattle on the road, 32-29.

The 49ers made it six-in-a-row last Monday night, as they saw off Washington at home, 23-17.

Atlanta Falcons 2-4 Following Back-To-Back Defeats

Atlanta go into their third straight home game having lost back-to-back matchups, leaving them 2-4.

The Falcons opened the season on the road, losing 20-13 in Pittsburgh, and then suffered a blowout defeat in their home opener, falling 34-3 to Carolina.

They finally got off the mark in Week 3 when they travelled to Green Bay to upset the Packers on Thursday Night Football, 35-14.

Atlanta backed that up with a 45-24 success in New Orleans, but they have not won since.

The Falcons suffered a 30-23 overtime defeat at the hands of Baltimore, and then lost 31-23 to Chicago in a game that was not as close as the final score suggests.

Verdict

SF 49ers @ ATL Falcons

The score does not suggest it, but Chicago pretty much dominated the Falcons a week ago.

San Francisco are more than capable of doing the same here, so we are backing the 49ers to make straightforward work of the faltering Falcons.

San Francisco -3.5

Spread

@1/1 - 4 Units

Bet £10 Get £30

with bonus code NEWBONUS

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Bet at bet365

Under 50.5

Total Points

@9/10 - 2 Units

Bet £10 Get £10

Promo Code: NEWBONUS

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Bet at dabble

US sports writer covering the NFL, NBA, NHL, boxing and MMA, with previews, predictions and betting tips across the major American leagues.

During his career at the Press Association and online sports sites including FreeTips and ExpertPicks.com, he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final.

He has also covered almost every major boxing match and UFC fight card during this time. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.

Follow more of Leigh's work on Muckrack and connect with him on LinkedIn.