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Seattle Seahawks at Arizona Cardinals Betting Tips – Underdog Cardinals Tipped For NFL Cover

leigh-copson
Editor
Last updated: Thu 17 Sep 2026 12:34
In their upcoming home game against the Seattle Seahawks, the Arizona Cardinals are tipped to cover the spread as home underdogs. The Cardinals pulled off an upset win over the Chargers in Week 1, showing balanced play on both offense and defense. Seattle welcomes backup QB Drew Lock after Sam Darnold’s injury, which could be an advantage for Arizona. Historically, the Seahawks lead the all-time series, but current injury woes and Arizona’s momentum make the Cardinals plus points a value bet. The Under is trending for both teams' games so far this season.
Leigh Copson 2 hours ago
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  • Cardinals are tipped to cover as home underdogs after impressing in Week 1
  • Seahawks will likely start backup QB Drew Lock
  • Both teams have cashed the Under in opening games; Arizona plus points offers value
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Arizona are tipped to cover as a home betting underdog.

The Cardinals played some good football on both sides of the ball in their surprise Week 1 win, and now they get to face a Seahawks team with error-prone Drew Lock under center.

Key Numbers – Can Cardinals Deliver As An Underdog Again?

  • Arizona Cardinals won as a betting underdog last weekend
  • Seattle Seahawks failed to cover in their Week 1 victory
  • The Under cashed in Arizona’s opening game
  • The Under hit in Seattle’s first game of the season

Seahawks Lead All-Time Head-To-Head; Won Last Meeting

  • Seattle Seahawks lead the all-time series 31-22-1
  • Seattle Seahawks won 44-22 when the two teams last met in November 2025

Seattle Seahawks Won Super Bowl Rematch

Seattle head out on the road for the first time this season, looking to build on their Week 1 win over New England.

The Seahawks and Patriots went head-to-head in rematch of last season’s Super Bowl, and the hosts again came out on top as they won 13-10.

They trailed by 10 points late in the third quarter, but turned things around as two Jason Myers field goals sandwiched a Jaxon Smith-Njigba touchdown catch.

Sam Darnold left the game with injury, and in his place Drew Lock went 16/22 for 187 yards and a touchdown.

Smith-Njigba led the team in receiving with 122 yards and a score, while Jadrian Price put up 52 yards off 10 carries.

Arizona Cardinals Upset Chargers In Week 1

Arizona go into their home opener on the back of an impressive season-opening win at the Los Angeles Chargers.

The Cardinals went into that match as 9.5-point underdogs, but produced a well-rounded display to run out 26-14 winners at SoFi Stadium.

Jacoby Brissett – named the starter in the offseason – went 27/37 for 277 yards and a touchdown.

Trey McBride was his favourite target, turning 13 targets into nine catches, 95 yards and a touchdown, while Omarion Hampton rushed for 43 yards and a score on 12 carries.

Over on defense, Jordan Burch and Dante Stills had a sack each, while Andrew Wingard registered an interception and forced a fumble that Will Johnson recovered.

Verdict

Arizona sprung an upset in Week 1, and they definitely offer appeal with the free points here.

They have home advantage over a Seahawks team that is missing its starting quarterback, so give us the Cardinals and the points.

Best Bet1: Arizona +3.5 Spread @9/10 at bet365 - 4 Units
Best Bet2: Under 41.5 Total Points @9/10 at dabble - 2 Units
Arizona +3.5
Spread
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Under 41.5
Total Points
@9/10 - 2 Units
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leigh-copson
Leigh Copson

Sports Editor • 25+ Years Experience, US & Combat Sports Specialist

During his career he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final. He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.


Follow more of Leigh's work on Muckrack.

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