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LSU at Ole Miss Betting Tips - Back Tigers In College Football’s Lane Griffin ‘Grudge Match’

leigh-copson
Editor
Last updated: Tue 15 Sep 2026 12:08
LSU are predicted to cover the spread as Lane Kiffin returns to Ole Miss with the Tigers, both teams holding undefeated records this season. LSU's offense has been explosive while their defense has been solid, shutting down opponents in consecutive games. Ole Miss scraped through a tight opener but followed with a strong win. LSU lead the all-time series, but Ole Miss won the last meeting. With the Tigers' superior form and Kiffin’s motivation, the tip is for LSU to win and cover the -3 point spread, with the expectation of a high-scoring game.
Leigh Copson 2 hours ago
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  • Lane Kiffin returns to Ole Miss with undefeated LSU (2-0)
  • LSU's explosive offense and strong defense tip odds in their favour
  • Experts predict LSU to cover the -3 spread and a high-scoring game
(Getty Images)

LSU are tipped to cover as Lane Kiffin enjoys a winning return to Ole Miss.

The Tigers still have some things to clean up after two weeks, but the offense has produced plenty of points through two games, while this defense has shut down back-to-back opponents.

Key Numbers – Will LSU Improve To 3-0?

  • LSU are a perfect 2-0 heading into Week 3
  • Ole Miss have failed to cover in each of their first 2 games
  • The winning team has covered in 9 of the previous 10 meetings
  • The Over has cashed in 3 of the first 4 games involving either team

LSU Lead All-Time Head-To-Head; Ole Miss Won Last Meeting

  • LSU lead the all-time series 65-39-3
  • Ole Miss won 24-19 when the two teams last met in September 2025

LSU Boast Perfect 2-0 Record Under Lane Kiffin

Lane Kiffin heads back to his old team this weekend having led LSU to a perfect 2-0 start.

Kiffin left Ole Miss for the Tigers in tumultuous fashion late last year, and he has enjoyed a flying start to his reign.

They kicked things off with a 51-10 blowout of Clemson – considered one of the most impressive performances by any team so far this season.

Sam Leavitt and Dilin Jones ran all over Clemson in the Death Valley rivalry game, combining for 226 yards and four touchdowns.

LSU then backed that up last weekend as the Tigers overcame a slow first half to beat Louisiana Tech 45-14.

Ole Miss Also Take Perfect Record Into Grudge Match

Ole Miss go into this clash with their former head coach also boasting a 100% record thanks to back-to-back wins.

The Rebels kicked off the campaign with a victory over Louisville, but it was hardly plain-sailing as they needed a walk-off field goal from Lucas Carneiro to see off the Cardinals, 41-38.

While the victory was far from convincing, quarterback Trinidad Chambliss showcased his talents with 336 yards and three touchdowns through the air, while also adding 60 yards and a score on the ground.

His favourite target on the day was Deuce Alexander, as the pair hooked up for 159 yards and two TDs.

Ole Miss followed up that victory with a convincing win last weekend, as they downed Charlotte, 41-9.

Verdict

LSU have the offense to hang plenty of points on Ole Miss and the defense to at least slow down Trinidad Chambliss & Co.

We expect Lane Kiffin to enjoy his first return to Vaught-Hemingway Stadium since ditching the Rebels for the Tigers.

Best Bet1: LSU -3.0 Spread @5/6 at bet365 - 4 Units
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leigh-copson
Leigh Copson

Sports Editor • 25+ Years Experience, US & Combat Sports Specialist

During his career he has covered some of the biggest sporting events on the planet, including the Super Bowl, the Champions League Final and the World Cup Final. He has also covered almost every major boxing match and UFC fight card during this time.. His specialist sports are American Football, Basketball, Ice Hockey, Boxing, Mixed Martial Arts and Football.


Follow more of Leigh's work on Muckrack.

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